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Selamectin

Selamectin

Identifiers
CAS number	165108-07-6
PubChem	9578507
SMILES	CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)O)OC)C)OC1C7CCCCC7
Properties
Molecular formula	C₄₃H₆₃NO₁₁
Molar mass	769.96 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Selamectin is the active ingredient in Revolution, a topical insecticide and antihelminthic used on dogs and cats. It controls fleas, heartworm, hookworms, roundworms, and ear mites. Because it is a heartworm preventative, selamectin requires a veterinarian's prescription.

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Selamectin works by replacing glutamate which normally interacts with receptors that open chloride channels at muscle synapses found in parasites. Unlike glutamate, selamectin activates the chloride current without desensitization, thereby producing prolonged hyperpolarization and impaired muscle contraction.

Category: Antiparasitic agents