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Rupatadine


Rupatadine
Systematic (IUPAC) name
8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridyl)methyl)- 4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
Identifiers
CAS number	158876-82-5
ATC code	R06AX28
PubChem	133017
Chemical data
Formula	C₂₆H₂₆Cl N₃
Mol. mass	415.958 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	99%
Metabolism	Hepatic, CYP-mediated
Half life	5.9 hours
Excretion	Fecal (60.9%) and renal (34.6%)
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Rupatadine is a new selective histamine H₁ receptor and platelet-activating factor (PAF) antagonist. Ruptatadine is marketed by Panacea-Biotech under the trade name Ralif. Ralif is approved for the treatment of allergic rhinitis.

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Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Olopatadine