To use all functions of this page, please activate cookies in your browser.
my.chemeurope.com
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Ritter reactionThe Ritter reaction is a chemical reaction that transforms a nitrile into a N-alkyl amide using various alkylating reagents, for example, strong acid and isobutylene.[1][2][3] Additional recommended knowledgePrimary[4], secondary[5], tertiary[6], and benzylic[7] alcohols, as well as tert-butyl acetate[8], also successfully react with nitriles in the presence of strong acids to form amides via the Ritter reaction. Reaction mechanismThe Ritter reaction proceeds by the electrophilic addition of either the carbenium ion 2 or covalent species[9][10] to the nitrile. The resulting nitrilium ion 3 is hydrolyzed by water to the desired amide 5. References
|
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ritter_reaction". A list of authors is available in Wikipedia. |