Tandem pore domain potassium channel

Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.^[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Additional recommended knowledge

Gene	Channel
KCNK1	K_2p01.1
KCNK2	K_2p02.1
KCNK3	K_2p03.1
KCNK4	K_2p04.1
KCNK5	K_2p05.1
KCNK6	K_2p06.1
KCNK7	K_2p07.1
KCNK9	K_2p09.1
KCNK10	K_2p10.1
KCNK12	K_2p12.1
KCNK13	K_2p13.1
KCNK15	K_2p15.1
KCNK16	K_2p16.1
KCNK17	K_2p17.1
KCNK18	K_2p18.1

References

^ ^a ^b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106.

v • d • e Membrane transport protein: ion channels
Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Na_vβ (1, 3, 4) • Epithelial sodium channel
K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain K2P (1, 2, 3, 4, 6, 9)
Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator
Porin	Aquaporin (1, 2, 3, 4) • Voltage-dependent anion channel (1)
Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6)
Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α3, β3, H1, H2, H4) • Stretch-activated ion channel