Related to receptor tyrosine kinase

The related to receptor tyrosine kinases (RYKs) are a family of proteins that are a members of the receptor tyrosine kinase family of cell surface receptors.

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History

The gene encoding mouse RYK was first identified in 1992.^[1] Subsequently cDNA encoding the RYK protein have been isolated from the following species.^[2]

• rat
• chicken
• Human
• Zebrafish
• Drosophila and
• C. elegans

Structure

In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal extracellular ligand binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.^[2]

References

1. ^ Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818-11822. PMID 1334548.
2. ^ ^{a b} Halford, MM, and Stacker, S.A. (2001). "Revelations of the RYK receptor". Bioessays 23 (1): 34-45. PMID 11135307.