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Reformatskii reactionThe Reformatskii reaction (often spelled Reformatsky reaction) is an organic reaction which condenses aldehydes 1 (or ketones) with α-halo esters 2 with metallic zinc to form β-hydroxy-esters 3. It was discovered by Sergei Nikolaevich Reformatskii. The organozinc reagent, also called a 'Reformatskii enolate', is prepared by treating an alpha-halo ester with zinc dust. Reformatskii enolates are less reactive than Grignard reagents and hence nucleophillic addition to the ester group does not occur. Some reviews have been published. Additional recommended knowledge
VariationsIn one variation of the Reformatsky reactioniodolactone is coupled with an aldehyde with triethylborane in toluene at -78°C. an
See also
References
See alsoCategories: Addition reactions | Carbon-carbon bond forming reactions |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Reformatskii_reaction". A list of authors is available in Wikipedia. |