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Rabeprazole
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It was developed by Eisai Co. and is marketed by Janssen-Cilag as rabeprazole sodium under the brand names Aciphex and Pariet. Additional recommended knowledge
PharmacologyRabeprazole is a prodrug (metabolized by the cytochrome P450 (or CYP450)) - in the acid environment of the parietal cells it turns into active sulphenamide form associated with cysteine of H+, K+ATPase (proton pump). Rabeprazole inhibits (partly reversibly) H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. Rabeprazole has anti Helicobacter pylori activity (MIC 4-16 mg/ml) and shows synergistic activity with some antibiotics. Rabeprazole has been demonstrated to be effective in patients with pathological hypersecretory activity (incl. Zollinger-Ellison Syndrome). Indications and usageContraindicationsRestriction of usageSide effectsRabeprazole Adverse reactions/Side effects include: Drug interactionsRabeprazole decreases the concentration of ketoconazole in the plasma (in 33%), increases the concentration of digoxin (in 22%), and does not interact with liquid antiacids. Rabeprazole is compatible with any medicine metabolized by the CYP450 (theophylline, warfarin, diazepam, phenytoin). OverdosageThere is no available data on symptoms of rabeprazole overdose. How suppliedRabeprazole as Aciphex,Rabeloc, Pariet is supplied in: References
Categories: Prodrugs | Proton pump inhibitors |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rabeprazole". A list of authors is available in Wikipedia. |