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Propentofylline


Propentofylline
Systematic (IUPAC) name
3-methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione
Identifiers
CAS number	55242-55-2
ATC code	N06BC02
PubChem	4938
Chemical data
Formula	C₁₅H₂₂N₄O₃
Mol. mass	306.360 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Propentofylline is a xanthine derivative and phosphodiesterase inhibitor with purported neuroprotective effects. It is being studied as a possible treatment for Alzheimer's disease and multi-infarct dementia.^[1]^[2]

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Propentofylline has also been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.^[3]^[4]

References

^ Frampton M, Harvey RJ, Kirchner V (2003). "Propentofylline for dementia". Cochrane database of systematic reviews (Online) (2): CD002853. doi:10.1002/14651858.CD002853. PMID 12804440.
^ Kittner B, Rössner M, Rother M (1997). "Clinical trials in dementia with propentofylline". Ann. N. Y. Acad. Sci. 826: 307–16. PMID 9329701.
^ Bath PM, Bath-Hextall FJ (2004). "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke". Cochrane database of systematic reviews (Online) (3): CD000162. doi:10.1002/14651858.CD000162.pub2. PMID 15266424.
^ Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD (1993). "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke". J. Cereb. Blood Flow Metab. 13 (3): 526–30. PMID 8478410.

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