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Prickle (protein)
The first prickle protein was identified in Drosophila as a planar cell polarity protein. Vertebrate prickle-1 was first found as a rat protein that binds to a transcription factor, neuron-restrictive silencer factor (NRSF). It was then recognized that other vertebrates including mice and humans have two genes that are related to Drosophila prickle[1]. Mouse prickle-2 was found to be expressed in mature neurons of the brain along with mouse homologs of Drosophila planar polarity genes flamingo and dischevelled[2].
Additional recommended knowledgePrickle is recruited to the cell surface membrane by strabismus, another planar cell polarity protein[3]. In the developing Drosophila wing, prickle becomes concentrated at the proximal side of cells[3]. Prickle can compete with the ankyrin-repeat protein Diego for a binding site on Dishevelled[4]. In Drosophila, prickle is present inside cells in multiple forms due to alternative splicing of the prickle mRNA[5]. The relative levels of the alternate forms may be regulated and involved in the normal control of planar cell polarity[5]. References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Prickle_(protein)". A list of authors is available in Wikipedia. |