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Pramocaine


Pramocaine
Systematic (IUPAC) name
4-[3-(4-butoxyphenoxy)propyl]morpholine
Identifiers
CAS number	140-65-8 637-58-1 (hydrochloride)
ATC code	D04AB07 C05AD07
PubChem	4886
Chemical data
Formula	C₁₇H₂₇N O₃
Mol. mass	293.401 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK) ℞-only(US) (with hydrocortisone)
Routes	Topical, rectal

Pramocaine (INN and BAN, also known as pramoxine) is a topical anesthetic used as an antipruritic.

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Popular itch cream Gold Bond uses pramocaine hydrochloride (hydrochloride used to ease absorption in the skin) to numb sensitive skin.

Usage

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches.^[1]

Notes

^ http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202042.html

v • d • e Vasoprotectives (C05)
Antihemorrhoidals for topical use	corticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide) - local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine) - other (Tribenoside)
Antivaricose therapy	heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate) - sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol) - Other (Calcium dobesilate)
Capillary stabilising agents	bioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)

v • d • e Antipruritics (D04)
Antihistamines for topical use	Thonzylamine - Mepyramine - Thenalidine - Tripelennamine - Chloropyramine - Promethazine - Tolpropamine - Dimetindene - Clemastine - Bamipine - Isothipendyl - Diphenhydramine - Chlorphenoxamine
Anesthetics for topical use	Lidocaine - Cinchocaine - Oxybuprocaine - Benzocaine - Quinisocaine - Tetracaine - Pramocaine