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Tandem pore domain potassium channel



Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:[1]

Gene Channel
KCNK1 K2p01.1
KCNK2 K2p02.1
KCNK3 K2p03.1
KCNK4 K2p04.1
KCNK5 K2p05.1
KCNK6 K2p06.1
KCNK7 K2p07.1
KCNK9 K2p09.1
KCNK10 K2p10.1
KCNK12 K2p12.1
KCNK13 K2p13.1
KCNK15 K2p15.1
KCNK16 K2p16.1
KCNK17 K2p17.1
KCNK18 K2p18.1

See also

References

  1. ^ a b Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106.
v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channelVoltage-dependent calcium channel (L-type/Cavα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Cavα(2.1), Q-type, R-type, T-type, β-subunits (β1, β2, β4), γ-subunits (γ2) • Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel
Na+: Sodium channelNavα (1.1, 1.2, 1.4, 1.5, 1.7, 1.9) • Navβ (1, 3, 4) • Epithelial sodium channel
K+: Potassium channelVoltage-gated (Kvα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 4.2, 4.3, 7.1, 7.2, 7.3, 7.4, 10.1, 11.1/hERG) • Kvβ (1, 2), Shaker gene, KCNE1) • Calcium-activated (BK channel, SK channel, SK3) • Inward-rectifier Kir (1.1, 2.1, 2.2, 2.3, 3.1, 3.2, 3.4, 4.1, 4.2, 6.1, 6.2)) • Tandem pore domain K2P (1, 2, 3, 4, 6, 9)
Cl-: Chloride channelCystic fibrosis transmembrane conductance regulator
PorinAquaporin (1, 2, 3, 4) • Voltage-dependent anion channel (1)
Cations: TRPTRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2)• TRPV (1, 2, 3, 4, 5, 6)
Other/generalVoltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α3, β3, H1, H2, H4) • Stretch-activated ion channel
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tandem_pore_domain_potassium_channel". A list of authors is available in Wikipedia.
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