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Phenylethanolamine N-methyltransferase



phenylethanolamine N-methyltransferase
Identifiers
Symbol PNMT
Alt. Symbols PENT
Entrez 5409
HUGO 9160
OMIM 171190
RefSeq NM_002686
UniProt P11086
Other data
EC number 2.1.1.28
Locus Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts Norepinephrine (Noradrenalin) to Epinephrine (Adrenalin).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

 
v • d • e
Transferase: one carbon transferases (EC 2.1)
2.1.1 - Methyltransferases5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Betaine-homocysteine methyltransferase - Catechol-O-methyl transferase - Histamine N-methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase - Phosphatidyl ethanolamine methyltransferase - Phenylethanolamine N-methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - Tryptamine N-methyltransferase - DNA methyltransferase
2.1.2 - Hydroxy methyl-, Formyl- and Related TransferasesSerine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase
2.1.3 - Carboxy- and Carbamoyl transferasesOrnithine transcarbamylase
2.1.4 - Amidino transferasesArginine:glycine amidinotransferase
v • d • e
Amino acid metabolism enzymes
phenylalanine→tyrosine→fumarate→TCAPhenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase
tyrosine→dopamine→epinephrineTyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase
leucine→HMG-CoA (keto)Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase
isoleucine/valine→propionyl-CoABranched-chain alpha-keto acid dehydrogenase complex
methionine→cysteine→propionyl-CoAMethionine adenosyltransferase - Adenosylhomocysteinase - (or MTR) - Cystathionine beta synthase - Cystathionine gamma-lyase
propionyl-CoA→succinyl-CoA→TCAPropionyl-CoA carboxylase - Methylmalonyl-CoA mutase
serine→glycineSerine hydroxymethyltransferase
histidineto histamine: Histidine decarboxylase - to glutamate: Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase
tryptophan→serotonin→melatoninTryptophan hydroxylase - Aromatic L-amino acid decarboxylase - 5-hydroxyindole-O-methyltransferase
asparagine→aspartate→oxaloacetate→TCAAsparaginase/Asparagine synthetase - Aspartate transaminase
glutamateGlutaminase - Glutamate decarboxylase
lysine→ketoSaccharopine dehydrogenase
otherTyrosinase
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Phenylethanolamine_N-methyltransferase". A list of authors is available in Wikipedia.
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