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Phenaridine


Phenaridine
Systematic (IUPAC) name
N-[2,5-dimethyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide
Identifiers
CAS number	42045-97-6
ATC code	?
PubChem	162056
Chemical data
Formula	C₂₄H₃₂N₂O
Mol. mass	364.52 g/mol
Synonyms	Phenaridine
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Phenaridine (2,5-Dimethylfentanyl) is an opioid analgesic that is an analogue of fentanyl. It was developed in the 1970s^[1], and is used for surgical anasthesia.^[2]^[3]

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Phenaridine has similar effects to fentanyl. It is slightly less potent than fentanyl in rats^[1]. Side effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression which can be life-threatening.^[4]

References

^ ^a ^b Riley NT, Hale DB, Wilson MV. 4-Anilidopiperidine Analgesics I: Synthesis and Analgesic Activity of Certain Ring-Methylated 1-Substituted 4-Propananilidopiperidines. J. Pharm. Sci 62(6): 983 (1973)
^ Osipova NA, Petrova VV, Novikov GA, Dolgopolova TV, Zhukova OI, Mel'nikova ZL, Smolina TA. The new Soviet narcotic analgesic phenaridine as a component of general anesthesia during cancer surgery. (Russian). Anesteziologiia i Reanimatologiia. 1991 Jan-Feb;(1):42-6.
^ Vlasenko EV, Durgarian LK, Azlivian AS, Sarukhanian KV. The evaluation of the analgesic action of phenaridine when combined with agents used in anesthesiological practice. (Russian). Farmakologiia i Toksikologiia. 1991 May-Jun;54(3):17-20.
^ Buniatian AA, Seleznev MN, Flerov EV, Iavorovskii AG, Sarukhanian KV, Vyzhigina MA. Balanced anesthesia using the new Russian analgesic fenaridina in cardiovascular surgery and its effect on hemodynamics and respiration. (Russian). Anesteziologiia i Reanimatologiia. 1993 Sep-Oct;(5):3-8.

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Opioids

Opiate derivatives

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Morphinans

Butorphanol • Cyclorphan • Dextro-3-hydroxy-N-allylmorphinan • Dextrorphan • Drotebanol • Levargorphan • Levallorphan • Levorphanol • Levorphan • Levophenacylmorphan • Levomethorphan • Norlevorphanol • Oxilorphan • Phenomorphan • Racemethorphan • Racemorphan

Benzomorphans

Bremazocine • Cyclazocine • Dezocine • Ethylketocyclazocine • Ketazocine • Metazocine • Pentazocine • Phenazocine

4-Phenylpiperidines

Pethidines (Meperidines)	Anileridine • Benzethidine • Carperidine • Difenoxin • Diphenoxylate • Etoxeridine (Carbetidine) • Furethidine • Hydroxypethidine (Bemidone) • Morpheridine • Oxpheneridine (Carbamethidine) • Pethidine (Meperidine) • Pethidine Intermediate A • Pethidine Intermediate B (Norpethidine) • Pethidine Intermediate C (Pethidinic Acid) • Pheneridine • Phenoperidine • Piminodine • Properidine (Ipropethidine) • Sameridine • WIN-7681
Prodines	Allylprodine • α-meprodine • α-prodine • β-meprodine • β-prodine • Meprodine • MPPP • PEPAP • Prodine • Prosidol • Trimeperidine
Ketobemidones	Acetoxyketobemidone • Ketobemidone • Methylketobemidone • Propylketobemidone
Others	Alvimopan • Loperamide • Picenadol

Open Chain Opioids

Amidones	Dextromethadone • Dipipanone • Isomethadone • Levomethadone • Methadone • Methadone Intermediate • Norpipanone • Phenadoxone (Heptazone) • Pipidone
Methadols	Acetylmethadol • α-methadol • α-acetylmethadol • β-methadol • β-acetylmethadol • Dimepheptanol • Levo-α-acetylmethadol • Noracymethadol
Moramides	Dextromoramide • Levomoramide • Moramide Intermediate • Racemoramide
Thiambutenes	Diethylthiambutene • Dimethylthiambutene • Ethylmethylthiambutene
Phenalkoxams	Dextropropoxyphene • Dimenoxadol • Dioxaphetyl Butyrate • Levopropoxyphene • Propoxyphene
Ampromides	Diampromide • Phenampromide • Propiram
Others	Lefetamine