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Pazinaclone



Pazinaclone
Systematic (IUPAC) name
2-(7-chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8- azaspiro[4.5]decan-8-yl)-2-oxoethyl]-3H-isoindol-1-one
Identifiers
CAS number 103255-66-9
ATC code  ?
PubChem 59743
Chemical data
Formula C25H23ClN4O4 
Mol. mass 478.928 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Pazinaclone (DN-2327) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and eszopiclone.

Pazinaclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but with less amnestic effects,[1] and at low doses it is a relatively selective anxiolytic, with sedative effects only appearing at higher doses.[2]

Pazinaclone produces its sedative and anxiolytic effects by acting as a partial agonist at GABAA benzodiazepine receptors, although pazinaclone is more subtype-selective than most benzodiazepines.[3]


References

  1. ^ Wada T, Fukuda N. Effect of a new anxiolytic, DN-2327, on learning and memory in rats. Pharmacology, Biochemistry and Behavior. 1992 Mar;41(3):573-9.
  2. ^ Suzuki M, Uchiumi M, Murasaki M. A comparative study of the psychological effects of DN-2327, a partial benzodiazepine agonist, and alprazolam. Psychopharmacology (Berlin). 1995 Oct;121(4):442-50.
  3. ^ Atack JR. The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opinion on Investigational Drugs. 2005 May;14(5):601-18.


v • d • e
Psycholeptics: hypnotics and sedatives (N05C)
BarbituratesPentobarbital - Amobarbital - Butobarbital - Barbital - Aprobarbital - Secobarbital - Talbutal - Vinylbital - Vinbarbital - Cyclobarbital - Heptabarbital - Reposal - Methohexital - Hexobarbital - Thiopental - Ethallobarbital - Allobarbital - Proxibarbal - Phenobarbital
AldehydesAcetylglycinamide chloral hydrate - Chloral hydrate - Chloralodol - Dichloralphenazone - Paraldehyde - Petrichloral
BenzodiazepineBrotizolam - Cinolazepam - Doxefazepam - Estazolam - Flunitrazepam - Flurazepam - Loprazolam - Lorazepam - Lormetazepam - Nitrazepam - Nimetazepam - Midazolam - Quazepam - Temazepam - Triazolam
PiperidinedioneGlutethimide - Methyprylon - Pyrithyldione
QuinazolinoneAfloqualone - Cloroqualone - Diproqualone - Etaqualone - Mebroqualone - Mecloqualone - Methaqualone - Methylmethaqualone
NonbenzodiazepineCL-218,872 - Eszopiclone - Indiplon - Necopidem - Pazinaclone - Saripidem - Suproclone - Suriclone - SX-3228 - Zaleplon - Zolpidem - Zopiclone
Melatonin receptorAgomelatine - Melatonin - Ramelteon
GHB TypeGABOB - GHB - GBL - 1,4-Butanediol
OtherApronal - Bromides - Bromisoval - Carbromal - Clomethiazole - Dexmedetomidine - Embutramide - Ethchlorvynol - Ethinamate - Hexapropymate - Methylpentynol - Niaprazine - Propiomazine - Scopolamine - Sulfonmethane - Trichloroethanol - Triclofos - Valerian - Valnoctamide
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pazinaclone". A list of authors is available in Wikipedia.
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