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Paromomycin sulfate



Paromomycin sulfate
Systematic (IUPAC) name
(2R,3S,4R,5R,6S)-5-amino-6-[(1R,2S,3S,4R,6S)-
4,6-diamino-2-[(2S,3R,4R,5R)-4-[(2R,3R,4R,5R,6S)-
3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]
oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-
3-hydroxy-cyclohexyl]oxy-2-(hydroxymethyl)oxane-3,4-diol
Identifiers
CAS number 1263-89-4
ATC code A07AA06
PubChem 165580
DrugBank ?
Chemical data
Formula C23H47N5O18S 
Mol. mass 615.629 g/mol
Pharmacokinetic data
Bioavailability None
Metabolism None
Half life  ?
Excretion Fecal
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

Schedule VI U.S.

Routes Oral, intramuscular

Paromomycin sulfate (brand name Humatin) is a drug that fights intestinal infections such as cryptosporidiosis and amoeba infection, or amoebiasis and was developed as a therapeutic against visceral leishmaniasis by the Institute for OneWorld Health. Paromomycin was granted orphan drug status in 2005[1] and was approved by the Drug Controller General of India in September 2006 for treatment of visceral leishmaniasis.[2]

Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA.[3]


References

  1. ^ Institute for OneWorld Health (23 May 2005). "Institute for OneWorld Health Drug Receives “Orphan” Designation From U.S. and European Regulatory Agencies". Press release. Retrieved on 2007-02-10.
  2. ^ Institute for OneWorld Health (8 September 2006). "New cure for deadly visceral leishmaniasis (kala-azar) approved by government of India". Press release. Retrieved on 2007-02-10.
  3. ^ Vicens, Quentin; Eric Westhof (August 2001). "Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site". Structure 9 (8): 647–658. doi:10.1016/S0969-2126(01)00629-3. PMID 11587639. Retrieved on 2007-02-10.


v • d • e
Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07)
Intestinal anti-infectivesAntibiotics (Neomycin, Nystatin, Natamycin, Streptomycin, Polymyxin B, Paromomycin, Amphotericin B, Kanamycin, Vancomycin, Colistin, Rifaximin)

Sulfonamides (Phthalylsulfathiazole, Sulfaguanidine, Succinylsulfathiazole)

other (Miconazole, Broxyquinoline, Acetarsol, Nifuroxazide, Nifurzide)
Intestinal adsorbentsCharcoal - Bismuth - Pectin - Kaolin - Crospovidone - Attapulgite - Diosmectite
AntipropulsivesDiphenoxylate - Opium - Loperamide - Difenoxin
Intestinal anti-inflammatory agentscorticosteroids acting locally (Prednisolone, Hydrocortisone, Prednisone, Betamethasone, Tixocortol, Budesonide, Beclometasone)

antiallergic agents, excluding corticosteroids (Cromoglicic acid)

aminosalicylic acid and similar agents (Sulfasalazine, Mesalazine, Olsalazine, Balsalazide)
Antidiarrheal micro-organismsSaccharomyces boulardii
Other antidiarrhealsAlbumin tannate - Ceratonia - Racecadotril
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Paromomycin_sulfate". A list of authors is available in Wikipedia.
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