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Parecoxib



Parecoxib
Systematic (IUPAC) name
N-{[4-(5-methyl-3-phenylisoxazol-4-yl)phenyl]
sulfonyl}propanamide
Identifiers
CAS number 202409-33-4
ATC code M01AH04
PubChem 119828
Chemical data
Formula C19H18N2O4S 
Mol. mass 370.422 g/mol
Pharmacokinetic data
Bioavailability 100%
Protein binding 98%
Metabolism Hepatic to valdecoxib and propionic acid
CYP extensively involved (mainly CYP3A4 and 2C9)
Half life 22 minutes (parecoxib)
8 hours (valdecoxib)
Excretion Renal (70%, metabolites)
Therapeutic considerations
Licence data

EU 

Pregnancy cat.

Not recommended

Legal status

POM(UK)

Routes Intravenous and intramuscular

Parecoxib is a water soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union.


v • d • e
Anti-inflammatory and antirheumatic products (M01)
Anti-inflammatory and
antirheumatic products, non-steroids		Butylpyrazolidines (Phenylbutazone, Mofebutazone, Oxyphenbutazone, Clofezone, Kebuzone)

Acetic acid derivatives and related substances (Indometacin, Sulindac, Tolmetin, Zomepirac, Diclofenac, Alclofenac, Bumadizone, Etodolac, Lonazolac, Fentiazac, Acemetacin, Difenpiramide, Oxametacin, Proglumetacin, Ketorolac, Aceclofenac, Bufexamac)

Oxicams (Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam)

Propionic acid derivatives (Ibuprofen, Naproxen, Ketoprofen, Fenoprofen, Fenbufen, Benoxaprofen, Suprofen, Pirprofen, Flurbiprofen, Indoprofen, Tiaprofenic acid, Oxaprozin, Ibuproxam, Dexibuprofen, Flunoxaprofen, Alminoprofen, Dexketoprofen)

Fenamates (Mefenamic acid, Tolfenamic acid, Flufenamic acid, Meclofenamic acid)

Coxibs (Celecoxib, Rofecoxib, Valdecoxib, Parecoxib, Etoricoxib, Lumiracoxib)

other anti-inflammatory and antirheumatic agents, non-steroids (Nabumetone, Niflumic acid, Azapropazone, Glucosamine, Benzydamine, Glucosaminoglycan polysulfate, Proquazone, Orgotein, Nimesulide, Feprazone, Diacerein, Morniflumate, Tenidap, Oxaceprol, Chondroitin sulfate)
Specific antirheumatic agentsQuinolines (Oxycinchophen) - Gold preparations (Sodium aurothiomalate, Sodium aurothiosulfate, Auranofin, Aurothioglucose, Aurotioprol) - Penicillamine/Bucillamine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Parecoxib". A list of authors is available in Wikipedia.
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