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Paracaspase

mucosa associated lymphoid tissue lymphoma translocation gene 1
Identifiers
Symbol	MALT1
Alt. Symbols	MLT
Entrez	10892
HUGO	6819
OMIM	604860
RefSeq	NM_173844
UniProt	Q9UDY8
Other data
Locus	Chr. 18 q21

Paracaspases (human: MALT1) are related to caspases present in animals and slime mold, in contrast to metacaspases which are present in plants, fungi and "protists".^[1]

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Paracaspases are more similar to caspases than metacaspases are, indicating that this group of (putative) proteases diverged from caspases from a common metacaspase ancestor. The phylogenetic distribution is a bit confusing, since slime mold diverged earlier than the animal/fungal split.

References

^ Uren A, O'Rourke K, Aravind L, Pisabarro M, Seshagiri S, Koonin E, Dixit V (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol Cell 6 (4): 961-7. PMID 11090634.

v • d • e Hydrolase: proteases (EC 3.4)
Exopeptidase 3.4.11-19	Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase Metalloexopeptidases: Aminopeptidase (Alanine, Cystinyl, Leucyl, Glutamyl) - Carboxypeptidase (A, B, C, E, Glutamate II)
Endopeptidase 3.4.21-24	Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases
Cathepsin 3.4.18,21,22,23	A - B - C - K - S