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Pangamic acid

Pangamic acid

IUPAC name	6-(2-Dimethylamino-acetoxy)-2,3,4,5-tetrahydroxy-hexanoic acid
Other names	Vitamin B15
Identifiers
CAS number	20858-86-0
SMILES	OC([C@H](O)[C@@H](O)[C@H](O)[C@H](O)COC(CN(C)C)=O)=O
Properties
Molecular formula	C₁₀H₁₉NO₈
Molar mass	281.26
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Pangamic acid is an ester derived from gluconic acid and dimethylglycine.^[1] It was first isolated by Ernst T. Krebs from apricot kernels,^[2] and has since been identified in some foods such as pulses.^[3]

Additional recommended knowledge

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Pangamic acid is also known as vitamin B₁₅, but it is not widely accepted as a vitamin because it has not been shown to be essential in the human diet, and a deficiency in consumption of pangamic acid is not associated with any disease.^[4]

The calcium salt of pangamic acid, calcium pangamate, is used as a mineral supplement.

References

^ Recent data on the structure of pangamic acid (vitamin B15). Telegdy Kovats, Laszlo; Berndorfer-Kraszner, Eva; Juhasz, Agnes; Gabor, Tamas. Acta Alimentaria Academiae Scientiarum Hungaricae (1976), 5(3), 281-8.
^ KREBS E T Sr; KREBS E T Jr; BEARD H H; MALIN R; HARRIS A T; BARTLETT C L Pangamic acid sodium: a newly isolated crystalline water-soluble factor; a preliminary report. International record of medicine and general practice clinics (1951), 164(1), 18-23.
^ Singh, Jagdev; Handa, Mrs. Geeta; Nandi, L. N.; Manavalan, R.; Atal, C. K. D-Gluconodimethylaminoacetic acid from natural sources. Indian Drugs (1983), 20(5), 185-9.
^ "Vitamin B15 - Pangamic Acid", Elson M. Haas M.D.