My watch list

PLAT domain

PLAT/LH2 domain
Identifiers
Symbol	PLAT
Pfam	PF01477
InterPro	IPR001024
SCOP	1lpa
OPM family	88
OPM protein	1zq4
Available PDB structures: 1zq4A:374-490 1lox :2-112 1bu8A:356-468 1hplB:351-461 1ethC:339-450 1lpaB:355-465 1gpl :355-465 1n8sA:355-465 1lpbB:355-465 1rp1 :356-467 1y4kA:40-143 2sblB:40-143 1fgoA:40-143 1fgmA:40-143 1yge :40-143 1fgtA:40-143 1f8nA:40-143 1fgqA:40-143 1fgrA:40-143 1rrhA:58-161 1rovA:58-161 1lnh :58-161 1no3A:58-161 1n8qA:58-161 1rrlB:58-161 1hu9A:58-161 1ik3A:58-161 1jnqA:58-161

PLAT domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.

Additional recommended knowledge

Daily Sensitivity Test

Essential Laboratory Skills Guide

How to quickly check pipettes?

This domain is found in a variety of membrane or lipid associated proteins. It forms a beta-sandwich composed of two sheets of four strands each^[1]^[2]^[3].

Human proteins containing this domain

ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC; LIPG; LOXHD1; LPL; PKD1; PKD1L1; PKD1L2; PKD1L3; PKDREJ; PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;

References

^ Bateman A, Sandford R (1999). "The PLAT domain: a new piece in the PKD1 puzzle". Curr. Biol. 9 (16): -. PMID 10469604.
^ Delrieu I, Waller CC, Mota MM, Grainger M, Langhorne J, Holder AA (2002). "PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes". Mol. Biochem. Parasitol. 121 (1): -. PMID 11985859.
^ Minor W, Tomchick DR, Phan P, Cymborowski M, Holman TR (2001). "Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1". Biochemistry 40 (25): 7509-7517. PMID 11412104.