P57 (glycoside)

P57 is an oxypregnane steroidal glycoside isolated from the African cactiform Hoodia gordonii. P57 is the only active constituent from this plant that has been reported to be responsible for the potential appetite suppressant activity of Hoodia extracts.

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In a rat study at Brown Medical School, intracerebroventricular injections of the purified P57 demonstrated that the compound has a likely central nervous system (CNS) mechanism of action. The studies demonstrated that the compound increases the content of ATP by 50-150% in hypothalamic neurons. In addition, third ventricle administration of P57 reduced subsequent 24-hour food intake by 40-60%.

See also

• Hoodia - for additional information about P57 and Hoodia gordonii
• Anorectic - for additional information about appetite suppressants

References

• MacLean, David B.; Lu-Guang Luo (September 2004). "Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside". Brain Research 1020 (1-2): 1-11. doi:10.1016/j.brainres.2004.04.041. PMID 15312781.
• Avula, Bharathi; Yan-Hong Wang, Rahul S. Pawar, Yatin J. Shukla, Brian Schaneberg, Ikhlas A. Khan (May-June 2006). "Determination of the appetite suppressant P57 in Hoodia gordonii plant extracts and dietary supplements by liquid chromatography/electrospray ionization mass spectrometry (LC-MSD-TOF) and LC-UV methods". Journal of AOAC International 89 (3): 606-611. PMID 16792058. Retrieved on 2006-07-11.