P53 upregulated modulator of apoptosis

The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.^[1] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.

See also

• Apoptosis
• Apoptosome
• Bcl-2
• Bcl-2-associated_X_protein (BAX)
• BH3 interacting domain death agonist (BID)
• Caspases
• Cytochrome c
• Noxa
• Mitochondrion

References

1. ^ Nakano, K.; and Vousden, K. H. (March 2001). "PUMA, a Novel Proaptotic Gene, is Induced by p53". Molecular Cell 7: 683-694.