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P-TEFb
Additional recommended knowledgePositive Transcription Elongation Factor b (P-TEFb) is the key factor regulating eukaryotic mRNA transcription at the level of elongation[3][4]. It is a cyclin dependent kinase, comprised of Cdk9 and in humans one of three cyclins, T1, T2, or K[5]. The kinase activities of P-TEFb (the phosphorylation of serine 2 at RNA polymerase C-terminal repeats, the recruitment of TAT-SF1, a spliceosome recruiter, and the phosphorylation of hSPT5, a 5' capping enzyme recruiter[6]) is required to relieve RNA polymerase II from the negative elongation properties of DSIF and NELF and enter productive elongation resulting in mRNA production[7]. P-TEFb is also a required cellular cofactor for HIV-Tat[8] and inhibition of P-TEFb blocks HIV replication[9]. References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "P-TEFb". A list of authors is available in Wikipedia. |