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Oxprenolol


Oxprenolol
Systematic (IUPAC) name
1-propan-2-ylamino-3-(2 -prop-2-enoxyphenoxy)-propan-2-ol
Identifiers
CAS number	6452-71-7
ATC code	C07AA02
PubChem	4631
Chemical data
Formula	C₁₅H₂₃N O₃
Mol. mass	265.348
Pharmacokinetic data
Bioavailability	20-70%
Metabolism	Hepatic
Half life	1-2hours
Excretion	Renal Lactic (In lactiferous females)
Therapeutic considerations
Pregnancy cat.	C(AU)
Legal status	℞ Prescription only
Routes	oral

Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris and abnormal heart rhythms. It is also used for treating high blood pressure.

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Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.^[1]

Oxprenolol is a potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.^{[citation needed]}

References

^ McDevitt DG (1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". Eur. Heart J. 8 Suppl M: 9-14. PMID 2897304.

v • d • e Beta blockers (C07)
Non-selective β antagonists	Metipranolol • Nadolol • Oxprenolol • Penbutolol • Pindolol • Propranolol • Timolol • Sotalol
β₁ antagonists (cardioselective)	Atenolol • Acebutolol • Betaxolol • Bisoprolol • Esmolol • Metoprolol • Nebivolol
Mixed α₁/β antagonists	Carvedilol • Labetalol