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Oxetacaine


Oxetacaine
Systematic (IUPAC) name
2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide]
Identifiers
CAS number	126-27-2
ATC code	C05AD06
PubChem	4621
Chemical data
Formula	C₂₈H₄₁N₃O₃
Mol. mass	467.643 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	1 hour
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral, topical

Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan and Brazil, but not the United States; oxetacaine was withdrawn from the UK market in 2002.

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Unlike most local anesthetics, oxetacaine is active even in strongly acidic conditions.^[1]

References

^ Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med 109: 664–8. PMID 13910333.

Category: Local anesthetics