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Nitisinone


Nitisinone
Systematic (IUPAC) name
2-[2-nitro-4-(trifluoromethyl)benzoyl] cyclohexane-1,3-dione
Identifiers
CAS number	104206-65-7
ATC code	A16AX04
PubChem	115355
DrugBank	APRD01141
Chemical data
Formula	C₁₄H₁₀F₃N O₅
Mol. mass	329.228 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	Approximately 54 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin.

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v • d • e Other alimentary tract and metabolism products (A16)
Amino acids and derivatives	Levocarnitine - Ademetionine - Levoglutamide - Mercaptamine - Carglumic acid - Betaine
Enzymes	Alglucerase - Imiglucerase - Agalsidase alfa - Agalsidase beta - Laronidase - Sacrosidase - Alglucosidase alfa - Galsulfase - Idursulfase
Various alimentary tract and metabolism products	Tioctic acid - Anethole trithione - Sodium phenylbutyrate - Nitisinone - Zinc acetate - Miglustat