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Oppenauer oxidationOppenauer oxidation, named after Rupert Viktor Oppenauer [1], is a gentle method for oxidizing secondary alcohols to ketones. Additional recommended knowledge
The method has been largely displaced by oxidation methods based on chromates (e.g. PCC) or dimethyl sulfoxide (e.g. Swern oxidation) or Dess-Martin oxidation. It is still used for the oxidation of acid labile substrates. An advantage of the Oppenauer reaction is its use of relatively inexpensive and non-toxic reagents. A variation that uses trichloroacetaldehyde and aluminium oxide is able to selectively oxidize secondary alcohols, leaving primary alcohols unchanged. In one modification [2] the catalyst is trimethylaluminium and the aldehyde 2-nitrobenzaldehyde for example in the oxidation of isoborneol to camphor: References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Oppenauer_oxidation". A list of authors is available in Wikipedia. |