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OgtO6-alkyl guanine transferase II (O6 AGT II) previously known as O6 Guanine transferase (ogt) is also part of the DNA repair system along with Ada [1]. Additional recommended knowledgeLike Ada, AGT II is responsible for the removal of alkyl groups from O6-alkyl guanine, O4-alkyl thymine and alkyl phosphotriester in the sugar-phosphate backbone of DNA.[1] AGT II shows a greater preference for O4-alkyl thymine than O6-alkyl guanine and alkyl phosphotriester. [1][2] Unlike Ada, AGT II is expressed constitutively in cells.[1][3] Therefore, AGT II will repair alkylated DNA adducts even before Ada is fully induced. AGT II is similar to Ada in its suicide inactivation-- AGT II transfers the alkyl group to a cysteine residue in its own structure, thereby inactivating itself.[1] The human equivalent of AGT II is MGMT (O6-methyl guanine methyl transferase). MGMT preferentially removes alkyl groups from O6-alkyl guanine than from O4–alkyl thymine.[1] References
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ogt". A list of authors is available in Wikipedia. |