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Disopyramide


Disopyramide
Systematic (IUPAC) name
4-dipropan-2-ylamino-2-phenyl-2-pyridin-2-yl-butanamide
Identifiers
CAS number	3737-09-5
ATC code	C01BA03
PubChem	3114
DrugBank	APRD00507
Chemical data
Formula	C₂₁H₂₉N₃O
Mol. mass	339.475 g/mol
Pharmacokinetic data
Bioavailability	High
Protein binding	50% to 65% (concentration-dependent)
Metabolism	Hepatic (CYP3A4-mediated)
Half life	6.7 hours (range 4 to 10 hours)
Excretion	Renal (80%)
Therapeutic considerations
Pregnancy cat.	B2(AU) C(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral, intravenous

Disopyramide (INN, trade names Norpace® and Rythmodan®) is an antiarrhythmic medication. It is a Class Ia antiarrythmic used in the treatment of ventricular tachycardias. It has no effect on alpha or beta adrenergic receptors.

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v • d • e Antiarrhythmic agents (C01B)
class Ia	Ajmaline • Disopyramide • Prajmaline • Procainamide • Quinidine • Sparteine
class Ib	Aprindine • Lidocaine • Mexiletine • Tocainide
class Ic	Encainide • Flecainide • Lorcainide • Moricizine • Propafenone
class II	Propranolol • Metoprolol • Nadolol • Atenolol • Acebutolol • Pindolol see Beta blockers (C07)
class III	Amiodarone • Bretylium tosylate • Bunaftine • Dofetilide • Ibutilide • Sotalol
class IV	Verapamil • Diltiazem see Calcium channel blockers (C08)
class V	Adenosine • Atropine • Digoxin