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Norfloxacin


Norfloxacin
Systematic (IUPAC) name
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline- 3-carboxylic acid
Identifiers
CAS number	70458-96-7
ATC code	J01MA06 S01AX12
PubChem	4539
DrugBank	APRD00469
Chemical data
Formula	C₁₆H₁₈F N₃O₃
Mol. mass	319.331 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	3 to 4 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Norfloxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections.

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Mechanism of action

The mechanism of action of norfloxacin involves inhibition of the A subunit of bacterial DNA gyrase, an enzyme which is essential for DNA replication.^[1]

References

^ Goldstein E (1987). "Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity". Am J Med 82 (6B): 3–17. PMID 3111257.

v • d • e Antibacterials for systemic use: quinolones (J01M)
Fluoroquinolones	Ciprofloxacin • Enoxacin • Fleroxacin • Gatifloxacin • Gemifloxacin • Grepafloxacin • Levofloxacin • Lomefloxacin • Moxifloxacin • Norfloxacin • Ofloxacin • Pefloxacin • Prulifloxacin • Rufloxacin • Sparfloxacin • Temafloxacin • Trovafloxacin • Sitafloxacin
Other quinolones	Cinoxacin • Flumequine • Nalidixic acid • Oxolinic acid • Pipemidic acid • Piromidic acid • Rosoxacin