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Nitazoxanide
Nitazoxanide, also known by the brand names Alinia and Annita, is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. It is approved for the treatment of infectious diarrhea caused by Cryptosporidium parvum and Giardia lamblia in patients 1 year of age and older. Nitazoxanide is currently in Phase II clinical trials for the treatment of hepatitis C, in combination with peginterferon alfa-2a and ribavirin.[1][2] Additional recommended knowledge
Adverse effectsSide effects are mostly gastrointestinal, and include abdominal pain, vomiting and diarrhea. PharmacokineticsNitazoxanide is a prodrug. Following oral administration, it is rapidly hydrolyzed to its active metabolite, tizoxanide, which is 99% protein bound. Peak concentrations are observed 1–4 hours after administration. It is excreted in the urine, bile and feces. ReferencesNotes
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Categories: Antiprotozoal agents | Nitro compounds | Prodrugs | Thiazoles |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nitazoxanide". A list of authors is available in Wikipedia. |