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Niaprazine



Niaprazine
Systematic (IUPAC) name
N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide
Identifiers
CAS number 27367-90-4
ATC code N05CM16
PubChem 71919
Chemical data
Formula C20H25FN4O 
Mol. mass 356.437
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 4.53 +- 0.86 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Oral

Niaprazine (Nopron) is a piperazine derivative drug which acts as a sedating antihistamine. It was invented in the 1970s [1], and is used in France, Italy and other european countries. It is mainly prescribed for its relatively strong sedative effects rather than as an antihistamine, and is used mainly for treating autism [2] and insomnia [3] in children and adolescents. Common side effects are: sedation during the day (especially during the first few days of treatment) and dizziness.


References

  1. ^ Duchene-Marullaz P, Rispat G, Perriere JP, Hache J, Labrid C. Some pharmacodynamical properties of niaprazine, a new antihistaminic agent. (French) Therapie. 1971 Nov-Dec;26(6):1203-9.
  2. ^ Rossi PG, Posar A, Parmeggiani A, Pipitone E, D'Agata M. Niaprazine in the treatment of autistic disorder. Journal of Child Neurology. 1999 Aug;14(8):547-50.
  3. ^ Younus M, Labellarte MJ. Insomnia in children: when are hypnotics indicated? Paediatric Drugs. 2002;4(6):391-403.
v • d • e
Psycholeptics: hypnotics and sedatives (N05C)
BarbituratesPentobarbital - Amobarbital - Butobarbital - Barbital - Aprobarbital - Secobarbital - Talbutal - Vinylbital - Vinbarbital - Cyclobarbital - Heptabarbital - Reposal - Methohexital - Hexobarbital - Thiopental - Ethallobarbital - Allobarbital - Proxibarbal - Phenobarbital
AldehydesAcetylglycinamide chloral hydrate - Chloral hydrate - Chloralodol - Dichloralphenazone - Paraldehyde - Petrichloral
BenzodiazepineBrotizolam - Cinolazepam - Doxefazepam - Estazolam - Flunitrazepam - Flurazepam - Loprazolam - Lorazepam - Lormetazepam - Nitrazepam - Nimetazepam - Midazolam - Quazepam - Temazepam - Triazolam
PiperidinedioneGlutethimide - Methyprylon - Pyrithyldione
QuinazolinoneAfloqualone - Cloroqualone - Diproqualone - Etaqualone - Mebroqualone - Mecloqualone - Methaqualone - Methylmethaqualone
NonbenzodiazepineCL-218,872 - Eszopiclone - Indiplon - Necopidem - Pazinaclone - Saripidem - Suproclone - Suriclone - SX-3228 - Zaleplon - Zolpidem - Zopiclone
Melatonin receptorAgomelatine - Melatonin - Ramelteon
GHB TypeGABOB - GHB - GBL - 1,4-Butanediol
OtherApronal - Bromides - Bromisoval - Carbromal - Clomethiazole - Dexmedetomidine - Embutramide - Ethchlorvynol - Ethinamate - Hexapropymate - Methylpentynol - Niaprazine - Propiomazine - Scopolamine - Sulfonmethane - Trichloroethanol - Triclofos - Valerian - Valnoctamide
v • d • e
Antihistamines (primarily R06)
Aminoalkyl ethersBromazine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylaminesBrompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediaminesChloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivativesAlimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivativesBuclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic useAntazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical useBamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroidsAntazoline • Azelastine
Other antiallergicsEmedastine • Epinastine • Ketotifen • Olopatadine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Niaprazine". A list of authors is available in Wikipedia.
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