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Nedocromil



Nedocromil
Systematic (IUPAC) name
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-
4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Identifiers
CAS number 69049-73-6
ATC code R01AC07 R03BC03, S01GX04
PubChem 50294
DrugBank APRD01137
Chemical data
Formula C19H17NO7 
Mol. mass 371.341 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 89%
Metabolism not metabolized
Half life ~3.3 hours
Excretion excreted unchanged
Therapeutic considerations
Pregnancy cat.

?

Legal status

POM(UK)

Routes Inhalation and eye drops

Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade.

Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes.

v • d • e
Decongestants and other nasal preparations (R01)
Topical: sympathomimetics, plainCyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine
Topical: antiallergic agents, excluding corticosteroidsCromoglicic acid - Levocabastine - Azelastine - Antazoline - Spaglumic acid - Thonzylamine - Nedocromil - Olopatadine
Topical: corticosteroidsBeclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone
Topical: other nasal preparationsCalcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin
Systemic use: SympathomimeticsPhenylpropanolamine - Pseudoephedrine - Phenylephrine
v • d • e
Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalantsShort acting β2-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline
Long acting β2-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol
other: Epinephrine • Isoproterenol • Orciprenaline
GlucocorticoidsBeclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone
AnticholinergicsIpratropium • Tiotropium
Mast cell stabilizersCromoglicate • Nedocromil
XanthinesAminophylline • Theobromine • Theophylline
Leukotriene antagonistsMontelukast • Pranlukast • Zafirlukast
Combination productsBudesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Nedocromil". A list of authors is available in Wikipedia.
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