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Naphthylisopropylamine



Naphthylisopropylamine
Systematic (IUPAC) name
2-(2-aminopropyl)naphthalene
Identifiers
CAS number  ?
ATC code  ?
PubChem  ?
Chemical data
Formula C13H15N 
Mol. mass 185.27 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Naphthylisopropylamine (PAL-287) is a stimulant drug developed for the treatment of amphetamine and cocaine addiction. PAL-287 acts by releasing dopamine and serotonin.[1]

In animal studies, PAL-287 was shown to reduce cocaine self-administration, yet produced relatively little stimulant effect when administered by itself, being a weaker stimulant than the comparison drug dexamphetamine.[2] PAL-287 is now under development to see whether it is a useful substitute drug for treating stimulant addiction in humans.


References

  1. ^ Rothman RB, Blough BE, Baumann MH. Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions. AAPS J. 2007 Jan 5;9(1):E1-10.
  2. ^ Richard B. Rothman, Bruce E. Blough, William L. Woolverton, Karen G. Anderson, S. Stevens Negus, Nancy K. Mello, Bryan L. Roth, and Michael H. Baumann. Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration. Journal of Pharmacology And Experimental Therapeutics. 2005; 313: 1361-1369.
v • d • e
Stimulants
EugeroicsAdrafinil • Armodafinil • Carphedon • Modafinil
Phenethylamines

4-Fluoroamphetamine • 4-Fluoromethamphetamine • 4-Methylmethcathinone • 4-MTA • α-PPP • Amphechloral • Amphetamine (Dexamphetamine, Adderall) • Amphetaminil • Benzphetamine • Bupropion • Cathinone • Chlorphentermine • Clobenzorex • Clortermine • Cypenamine • Diethylpropion • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone • Diphenyl prolinol • Ephedrine • Epinephrine • Ethcathinone • Ethylamphetamine • Fencamfamine • Fenethylline • Fenfluramine • Fenproporex • Feprosidnine • Furfenorex • Levomethamphetamine • Lisdexamfetamine • MDMA • Mefenorex • Methamphetamine • Methcathinone • Methoxyphedrine • Methylone • Octopamine • Parahydroxyamphetamine • PMA • PMEA • PMMA • PPAP • Phendimetrazine • Phenmetrazine • Phentermine • Phenylephrine • Phenylpropanolamine • Prolintane  Propylamphetamine • Pseudoephedrine • Selegiline • Synephrine • Xylopropamine

Piperazines

BZP • MeOPP • MBZP • mCPP • 2C-B-BZP

XanthinesCaffeine • Aminophylline • Paraxanthine • Theobromine • Theophylline
Tropanes

Brasofensine • CFT • Cocaethylene • Cocaine • Lometopane • RTI-121 • Tesofensine • Troparil

CholinergicsArecoline • Cotinine • Nicotine
ConvulsantsBicuculline • Gabazine • Pentetrazol • Picrotoxin • Strychnine • Thujone
Phenylaminooxazoles
Others
See also Sympathomimetic amines
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Naphthylisopropylamine". A list of authors is available in Wikipedia.
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