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Nalidixic acid


Nalidixic acid
Systematic (IUPAC) name
1-ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid
Identifiers
CAS number	389-08-2
ATC code	J01MB02
PubChem	4421
DrugBank	APRD01133
Chemical data
Formula	C₁₂H₁₂N₂O₃
Mol. mass	232.235 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	90%
Metabolism	Partially Hepatic
Half life	6-7 hours, significantly longer in renal impairment
Excretion	?
Therapeutic considerations
Pregnancy cat.	B U.S.
Legal status
Routes	Oral

Nalidixic acid (tradenames Neggram® and Wintomylon®) is the basis for quinolone antibiotics.

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Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts bacteriostatically (that is, it inhibits growth and reproduction). In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth.

It is especially used in treating urinary tract infections, caused for example by Escherichia coli, Proteus, Shigella, Enterobacter and Klebsiella.

v • d • e Antibacterials for systemic use: quinolones (J01M)
Fluoroquinolones	Ciprofloxacin • Enoxacin • Fleroxacin • Gatifloxacin • Gemifloxacin • Grepafloxacin • Levofloxacin • Lomefloxacin • Moxifloxacin • Norfloxacin • Ofloxacin • Pefloxacin • Prulifloxacin • Rufloxacin • Sparfloxacin • Temafloxacin • Trovafloxacin • Sitafloxacin
Other quinolones	Cinoxacin • Flumequine • Nalidixic acid • Oxolinic acid • Pipemidic acid • Piromidic acid • Rosoxacin