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N-Myc




V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Identifiers
Symbol(s) MYCN; MODED; N-myc; NMYC; ODED
External IDs OMIM: 164840 MGI: 97357 Homologene: 3922
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 4613 18109
Ensembl ENSG00000134323 ENSMUSG00000037169
Uniprot P04198 Q3UII1
Refseq NM_005378 (mRNA)
NP_005369 (protein) 		NM_008709 (mRNA)
NP_032735 (protein)
Location Chr 2: 16 - 16 Mb Chr 12: 12.96 - 12.97 Mb
Pubmed search [1] [2]

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), also known as MYCN, is a human gene.


This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.[1]


See also

References

  1. ^ Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian).

Further reading

  • Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network.". Gene 277 (1-2): 1-14. PMID 11602341.
  • Armstrong BC, Krystal GW (1992). "Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.". Cell Growth Differ. 3 (6): 385-90. PMID 1419902.
  • Hagiwara T, Nakaya K, Nakamura Y, et al. (1992). "Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II.". Eur. J. Biochem. 209 (3): 945-50. PMID 1425701.
  • Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1).". Nucleic Acids Res. 20 (5): 1165. PMID 1549498.
  • Krystal GW, Armstrong BC, Battey JF (1990). "N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.". Mol. Cell. Biol. 10 (8): 4180-91. PMID 1695323.
  • Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc.". Science 251 (4998): 1211-7. PMID 2006410.
  • Emanuel BS, Balaban G, Boyd JP, et al. (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas.". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736-40. PMID 2582423.
  • Ibson JM, Rabbitts PH (1988). "Sequence of a germ-line N-myc gene and amplification as a mechanism of activation.". Oncogene 2 (4): 399-402. PMID 2834684.
  • Stanton LW, Schwab M, Bishop JM (1986). "Nucleotide sequence of the human N-myc gene.". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1772-6. PMID 2869488.
  • Michitsch RW, Melera PW (1985). "Nucleotide sequence of the 3' exon of the human N-myc gene.". Nucleic Acids Res. 13 (7): 2545-58. PMID 2987858.
  • Slamon DJ, Boone TC, Seeger RC, et al. (1986). "Identification and characterization of the protein encoded by the human N-myc oncogene.". Science 232 (4751): 768-72. PMID 3008339.
  • Garson JA, van den Berghe JA, Kemshead JT (1987). "Novel non-isotopic in situ hybridization technique detects small (1 Kb) unique sequences in routinely G-banded human chromosomes: fine mapping of N-myc and beta-NGF genes.". Nucleic Acids Res. 15 (12): 4761-70. PMID 3299258.
  • Stanton LW, Bishop JM (1988). "Alternative processing of RNA transcribed from NMYC.". Mol. Cell. Biol. 7 (12): 4266-72. PMID 3437890.
  • Kohl NE, Legouy E, DePinho RA, et al. (1986). "Human N-myc is closely related in organization and nucleotide sequence to c-myc.". Nature 319 (6048): 73-7. doi:10.1038/319073a0. PMID 3510398.
  • Grady EF, Schwab M, Rosenau W (1987). "Expression of N-myc and c-src during the development of fetal human brain.". Cancer Res. 47 (11): 2931-6. PMID 3552210.
  • Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA.". Mol. Cell. Biol. 6 (12): 4450-7. PMID 3796607.
  • Brodeur GM, Seeger RC (1986). "Gene amplification in human neuroblastomas: basic mechanisms and clinical implications.". Cancer Genet. Cytogenet. 19 (1-2): 101-11. PMID 3940169.
  • Kanda N, Schreck R, Alt F, et al. (1983). "Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 80 (13): 4069-73. PMID 6575396.
  • Schwab M, Varmus HE, Bishop JM, et al. (1984). "Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.". Nature 308 (5956): 288-91. PMID 6700732.
  • Brodeur GM, Seeger RC, Schwab M, et al. (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.". Science 224 (4653): 1121-4. PMID 6719137.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "N-Myc". A list of authors is available in Wikipedia.
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