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Mezlocillin



Mezlocillin
Systematic (IUPAC) name
(2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-
2-oxo-imidazolidine-1-carbonyl)amino]-2-phenyl-acetyl]
amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-
carboxylic acid
Identifiers
CAS number 51481-65-3
ATC code J01CA10
PubChem 656511
DrugBank APRD01113
Chemical data
Formula C21H25N5O8S2 
Mol. mass 539.584 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 16–59%
Metabolism Hepatic (20–30%)
Half life 1.3–4.4 hours
Excretion Renal (50%) and biliary
Therapeutic considerations
Pregnancy cat.

B

Legal status
Routes Intravenous, intramuscular

Mezlocillin is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria.

Contents

Mechanism of action

Main article: Beta-lactam antibiotic

Like all other beta-lactam antibiotics, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis by binding to penicillin binding proteins. This ultimately leads to cell lysis.

Susceptible organisms

Gram-negative

  • Bacteroides spp., including B. fragilis
  • Enterobacter spp.
  • Escherichia coli
  • Haemophilus influenzae
  • Klebsiella species
  • Morganella morganii
  • Neisseria gonorrhoeae
  • Proteus mirabilis
  • Proteus vulgaris
  • Providencia rettgeri
  • Pseudomonas spp., including P. aeruginosa
  • Serratia marcescens

Gram-positive

  • Enterococcus faecalis
  • Peptococcus spp.
  • Peptostreptococcus spp.


v • d • e
Antibacterials for systemic use: beta-lactam antibiotics - penicillins (J01C)
AntibioticsAmoxicillin • Ampicillin • Azlocillin • Carbenicillin • Cloxacillin • Dicloxacillin • Flucloxacillin • Mezlocillin • Nafcillin • Piperacillin • Pivampicillin • Ticarcillin
Beta-lactamase inhibitorsSulbactam • Tazobactam • Clavulanic acid
CombinationsAmpicillin/sulbactam (Sultamicillin) • Co-amoxiclav
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mezlocillin". A list of authors is available in Wikipedia.
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