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Mevastatin


Mevastatin
Systematic (IUPAC) name
Compactin
Identifiers
CAS number	73573-88-3
ATC code	?
PubChem	64715
DrugBank	EXPT00012
Chemical data
Formula	C₂₃H₃₆O₆
Mol. mass	408.534 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Mevastatin, compactin, ML-236B is a hypolipidemic agent that belongs to the statins class.

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It was the first compound isolated in the 70s during research into HMG-CoA reductase inhibitors produced by a mould Penicillium citrinum.

Mevastatin is not used in therapy of hyperlipidemias because of multiple side effects but it is the only source for production of other statin - pravastatin.

v • d • e Lipid modifying agents (C10)
Statins	Atorvastatin • Cerivastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Simvastatin
Fibrates	Clofibrate • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride
Bile acid sequestrants	Colestyramine • Colestipol • Colextran • Colesevelam
Niacin and derivatives	Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox
Other	Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Ezetimibe