Metaclazepam

Metaclazepam (Talis) is a drug which is a benzodiazepine derivative. It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam.^[1]

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Metaclazepam is slightly more effective as an anxiolytic than bromazepam,^[2] or diazepam,^[3] with a 15mg dose of metaclazepam equivalent to 4mg of bromazepam.^[4]

References

1. ^ Buschmann G, Kuhl UG, Rohte O. General pharmacology of the anxiolytic compound metaclazepam in comparison to other benzodiazepines. Arzneimittelforschung. 1985;35(11):1643-55.
2. ^ Bilone F, Roncari R. A double-blind comparison of the anxiolytic activity of two benzodiazepines, metaclazepam and bromazepam, in anxiety neurosis. Current Medical Research and Opinion. 1988;11(1):45-7.
3. ^ Laakmann G, Blaschke D, Hippius H, Schewe S. Double-blind study of metaclazepam versus diazepam treatment of outpatients with anxiety syndrome. Pharmacopsychiatry. 1989 May;22(3):120-5.
4. ^ Marano P, Patti F, Nicoletti F. Controlled study on the anxiolytic activity of a newly-developed benzodiazepine, metaclazepam. Current Medical Research and Opinion. 1988;11(1):41-4.