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Mesna



Mesna
Systematic (IUPAC) name
sodium 2-sulfanylethanesulfonate
Identifiers
CAS number 19767-45-4
ATC code R05CB05 V03AF01
PubChem 29769
Chemical data
Formula C2H5NaO3S2 
Mol. mass 164.181 g/mol
Pharmacokinetic data
Bioavailability 45–79% (Oral)
Metabolism Oxidised in circulation
Half life 0.36–8.3 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

B1 (Au), B (U.S.)

Legal status

S4 (Au), POM (UK), ℞-only (U.S.)

Routes Oral, intravenous

Mesna (INN) (pronounced /ˈmɛznə/) is an adjuvant used in cancer chemotherapy involving cyclophosphamide and ifosfamide. It is currently marketed by Baxter as Uromitexan® and Mesnex®.

Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. These two anticancer agents, in vivo, may be converted to urotoxic metabolites such as acrolein. Mesna assists to neutralise these metabolites by binding through its sulfhydryl-moieties, and also increases urinary excretion of cysteine.

v • d • e
Cough and cold preparations (R05)
ExpectorantsTyloxapol - Potassium iodide - Guaifenesin - Ipecacuanha - Althea root - Senega - Antimony pentasulfide - Creosote - Guaiacolsulfonate - Levoverbenone
MucolyticsAcetylcysteine - Bromhexine - Carbocisteine - Eprazinone - Mesna - Ambroxol - Sobrerol - Domiodol - Letosteine - Stepronin - Tiopronin - Dornase alfa - Neltenexine - Erdosteine
Cough suppressants:
Opium alkaloids and derivatives		Ethylmorphine - Hydrocodone - Codeine - Normethadone - Noscapine - Pholcodine - Dextromethorphan - Thebacon - Dimemorfan - Acetyldihydrocodeine - Zipeprol
Other cough suppressantsBenzonatate - Benproperine - Clobutinol - Isoaminile - Pentoxyverine - Oxolamine - Oxeladin - Clofedanol - Pipazetate - Bibenzonium bromide - Butamirate - Fedrilate - Dibunate - Droxypropine - Prenoxdiazine - Dropropizine - Cloperastine - Meprotixol - Piperidione - Tipepidine - Morclofone - Nepinalone - Levodropropizine - Dimethoxanate
v • d • e
Detoxifying agents for antineoplastic treatment (V03AF)
Mesna - Dexrazoxane - Calcium folinate - Calcium levofolinate - Amifostine - Sodium folinate - Rasburicase - Palifermin
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mesna". A list of authors is available in Wikipedia.
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