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Mepyramine



Mepyramine
Systematic (IUPAC) name
N1-(4-methoxybenzyl)- N2,N2-dimethyl- N1-(pyridin-2-yl)ethane- 1,2-diamine
Identifiers
CAS number 91-84-9
ATC code R06AC01 D04AA02
PubChem  ?
Chemical data
Formula C17H23N3O 
Mol. mass 285.38 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Mepyramine (INN, also known as pyrilamine) [1] is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect.

It is used in over-the-counter combination products for colds and menstrual symptoms.[2]

Side effects may include sedation/drowsiness, muscle weakness, and insomnia.[3]

References

  1. ^ Parsons, M. E. and Ganellin, C. R. (2006). "Histamine and its receptors". British Journal of Pharmacology 147: S127–S135. PMID 16402096.
  2. ^ http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Cons/sep00cyp.cfm
  3. ^ http://www.drugs.com/pdr/pyrilamine_maleate.html


v • d • e
Antipruritics (D04)
Antihistamines for topical useThonzylamine - Mepyramine - Thenalidine - Tripelennamine - Chloropyramine - Promethazine - Tolpropamine - Dimetindene - Clemastine - Bamipine - Isothipendyl - Diphenhydramine - Chlorphenoxamine
Anesthetics for topical useLidocaine - Cinchocaine - Oxybuprocaine - Benzocaine - Quinisocaine - Tetracaine - Pramocaine
v • d • e
Antihistamines (primarily R06)
Aminoalkyl ethersBromazine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylaminesBrompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediaminesChloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivativesAlimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivativesBuclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic useAntazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical useBamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroidsAntazoline • Azelastine
Other antiallergicsEmedastine • Epinastine • Ketotifen • Olopatadine
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mepyramine". A list of authors is available in Wikipedia.
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