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Melperone


Melperone
Systematic (IUPAC) name
1-(4-fluorophenyl)-4-(4-methyl-1-piperidyl)butan-1-one
Identifiers
CAS number	3575-80-2
ATC code	N05AD03
PubChem	15387
Chemical data
Formula	C₁₆H₂₂F N O
Mol. mass	263.35 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic (inhibits CYP2D6^[1])
Half life	3–4 hours (oral) 6 hours (IM)
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral, intramuscular injection

Melperone (INN, also known as methylperone) is a butyrophenone atypical antipsychotic. It is sold under the trade names Buronil, Burnil, and Eunerpan.

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Chemistry

Appearance: White, crystalline odorless powder
Solubility: Freely soluble in water. Freely soluble in ethanol 99.5% and chloroform. Practically insoluble in diethyl ether.
Melting Point: 205-210C
pH (1% in water): 4.5-6.5
Stability: 48 months

It is a white crystalline powder that is manufactured by Dupont Chemoswed (Sweden). It is a butyrophenone (1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone hydrochloride).

References

^ Grözinger M, Dragicevic A, Hiemke C, Shams M, Müller MJ, Härtter S (2003). "Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine". Pharmacopsychiatry 36 (1): 3–6. doi:10.1055/s-2003-38084. PMID 12649767.

v • d • e Psycholeptics: antipsychotics (N05A)
Phenothiazine typical antipsychotics	Chlorpromazine • Fluphenazine • Mesoridazine • Perphenazine • Prochlorperazine • Promazine • Thioridazine/Sulforidazine • Trifluoperazine
Other typical antipsychotics	Indoles (Molindone) • Butyrophenones (Azaperone, Benperidol, Droperidol, Haloperidol, Trifluperidol) • Thioxanthenes (Flupentixol, Chlorprothixene, Thiothixene, Zuclopenthixol) • diphenylbutylpiperidines (Fluspirilene, Penfluridol, Pimozide) • other (Loxapine)
Atypical antipsychotics	Butyrophenones (Melperone) • Indoles (Sertindole, Ziprasidone) • Benzamides (Sulpiride, Remoxipride, Amisulpride) • diazepines/oxazepines/thiazepines (Clozapine, Olanzapine, Quetiapine) • other (Aripiprazole, Risperidone, Paliperidone, Asenapine, Iloperidone, Zotepine)