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MeglitinideThe meglitinide class of drugs treat diabetes type 2 Additional recommended knowledgeThey bind to an ATP-dependent K+ (KATP) channel on the cell membrane of pancreatic beta cells in a similar manner to sulfonylureas but at a separate binding site. This inhibits a tonic, hyperpolarizing outflux of potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
DrugsThe main branded drug in the meglitinide class is Novo Nordisk's repaglinide (Prandin), which gained FDA approval in 1997. Another type of drug in this class is nateglinide (Starlix). These drugs should be taken 0-30 minutes prior to eating. Follow the instructions given to you by your physician/nurse. Side-effectsSide effects include weight gain and hypoglycemia. While the potential for hypoglycemia is less than for those on sulfonylureas, it is still a serious potential side effect that can be life-threatening. Patients on this medication should know the signs and symptoms of hypoglycemia and appropriate action to take.
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Meglitinide". A list of authors is available in Wikipedia. |