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Methylcobalamin



Methylcobalamin
Systematic (IUPAC) name
?
Identifiers
CAS number	13422-55-4
ATC code	B03BA05
PubChem	6436232
Chemical data
Formula	C₆₃H₉₁Co N₁₃O₁₄P
Mol. mass	1344.38 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	oral,subliungal,injection.

Methylcobalamin is a cobalamin (MeB₁₂) used in peripheral neuropathy, diabetic neuropathy etc. It is a form of vitamin B₁₂. It has been studied in conjunction with sleep-wake rhythm disorders, where it appears to yield benefits, but at a low or inconsistent level.^[1]

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It is used in vitamin B12 deficiency (pernicious anemia) treatment.

Availability

Square Pharmaceuticals Ltd. Bangladesh manufactures this drug under the trade name Methicol.

Cipla Ltd manufactures this drug in India under the trade name Mecovit.

Bosnalijek of Bosnia and Herzegovina manufactures this drug under the trade name Cobal.

References

^ Double-blind test on the efficacy of methylcobalamin on sleep-wake rhythm disorders

v • d • e Vitamins (A11)
fat soluble	A (Retinol, Beta-carotene, Tretinoin, Alpha-carotene) - D (Ergocalciferol, Cholecalciferol, Dihydrotachysterol, Calcitriol, Calcidiol) - E (Tocopherol, Tocotrienol) - K (Naphthoquinone, Phylloquinone/K1, Menatetrenone/K2)
water soluble: B vitamins	B₁ (Thiamine, Sulbutiamine, Benfotiamine) - B₂ (Riboflavin) - B₃ (Niacin, Nicotinamide) - B₅ (Pantothenic acid, Dexpanthenol, Pantethine) - B₆ (Pyridoxine, Pyridoxal phosphate) - B₇ (Biotin) - B₉ (Folic acid) - B₁₂ (Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide)
water soluble: other	C (Ascorbic acid) - Choline

v • d • e Types of enzyme cofactors
Coenzymes	NAD⁺ - NADP⁺ - Coenzyme A - Tetrahydrofolic acid - Menaquinone - Ascorbic acid - Coenzyme F420 - Adenosine triphosphate - S-Adenosyl methionine - 3'-Phosphoadenosine-5'-phosphosulfate - Coenzyme Q - Tetrahydrobiopterin - Cytidine triphosphate - Glutathione - Coenzyme M - Coenzyme B - Methanofuran - Tetrahydromethanopterin
Prosthetic groups: Organic group	Flavin mononucleotide - Flavin adenine dinucleotide - Pyrroloquinoline quinone - Pyridoxal phosphate - Biotin - Methylcobalamin - Cobamamide - Thiamine pyrophosphate - Heme - Molybdopterin - Lipoic acid
Prosthetic groups: Metals	Calcium - Copper - Iron - Magnesium - Manganese - Nickel - Zinc