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Mebeverine



Mebeverine
Systematic (IUPAC) name
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Identifiers
CAS number	?
ATC code	A03AA04
PubChem	?
Chemical data
Formula	C₂₅H₃₆N O₅
Mol. mass	430.5595 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Mebeverine HCI is a musculotropic antispasmodic drug without atropic side-effects whose major therapeutic role is in the treatment of irritable bowel syndrome. It is also indicated for treatment of gastrointestinal spasm secondary to organic disorder. It was first registered in 1965 and manufacture by Solvay Pharmaceuticals.

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Mebeverine HCI presented in tablets (100mg or 135mg), capsules (200mg slow release), and liquid (10mg/ml).

Mode of Action

Mebeverine HCI belongs to a group of compounds called musculotropic antispasmodics. These compounds act directly on the gut muscles at the cellular level to relax them. Mebeverine is also an inhibitor of calcium-depot replenishment. Therefore, mebeverine has dual mode of action which normalizes the small bowel motility.

v • d • e

Drugs for functional gastrointestinal disorders (A03)

Drugs for functional bowel disorders

antimuscarinics: Mebeverine - Dicycloverine - Propantheline

papaverine and derivatives: Papaverine - Drotaverine - Moxaverine

acting on serotonin receptors: 5-HT₃ antagonists (Alosetron, Cilansetron) - 5HT₄ agonists (Mosapride, Tegaserod)