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Mafosfamide



Mafosfamide
IUPAC name 2-{[2-[bis(2-chloroethyl)amino]-2-oxo-
1-oxa-3-aza-2λ5-phosphacyclohex-
4-yl}sulfanyl]ethanesulfonic acid
Identifiers
CAS number 88859-04-5
PubChem 104746
MeSH Mafosfamide
SMILES C1COP(=O)(NC1SCCS(=O)(=O)O)N(CCCl)CCCl
Properties
Molecular formula C9H19Cl2N2O5PS2
Molar mass 401.269 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. Several Phase I trials have been completed.[1][2]

References

  1. ^ Intrathecal Mafosfamide. ClinicalTrials.gov. U.S. National Institutes of Health (August 21 2006). Retrieved on 2007-07-13. ClinicalTrials.gov Identifier NCT00062881.
  2. ^ Mafosfamide in Treating Patients With Progressive or Refractory Meningeal Tumors. ClinicalTrials.gov. U.S. National Institutes of Health (February 20 2007). Retrieved on 2007-07-13. ClinicalTrials.gov Identifier NCT00031928.
v • d • e
Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating and alkylating-like agentsNitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan). Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin). Platinum (alkylating-like): (Carboplatin, Cisplatin, Oxaliplatin, BBR3464). Busulfan, Dacarbazine, Procarbazine, Temozolomide, ThioTEPA, Uramustine
AntimetabolitesFolic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine). Pyrimidine:(Capecitabine, Cytarabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison/mitotic inhibitorTaxane: (Docetaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibioticsAnthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Valrubicin) - streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
Topoisomerase inhibitorsCamptotheca: (Camptothecin, Topotecan, Irinotecan), Podophyllum:(Etoposide, Teniposide)
CI monoclonal antibodiesReceptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Gemtuzumab)
PhotosensitizersAminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Tyrosine kinase inhibitorsDasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Nilotinib, Sorafenib, Sunitinib
Otherretinoids (Alitretinoin, Tretinoin) - Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Bexarotene, Bortezomib, Denileukin diftitox, Estramustine, Ixabepilone, Masoprocol, Mitotane
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mafosfamide". A list of authors is available in Wikipedia.
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