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MLL1




myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
Identifiers
Symbol MLL
Entrez 4297
HUGO 7132
OMIM 159555
RefSeq NM_005933
UniProt Q03164
Other data
Locus Chr. 11 q23

MLL1 or mixed-lineage leukemia 1 is a histone methyltransferase deemed a positive global regulator of gene transcription. This protein belongs to the group of histone-modifying enzymes and is involved in the epigenetic maintenance of transcriptional memory and the pathogenesis of human leukemias.[1] It also may participate in the process of GAD67 downregulation in schizophrenia.[2]

References

  1. ^ Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, Young RA (2005). "Global and Hox-specific roles for the MLL1 methyltransferase". Proc. Natl. Acad. Sci. U.S.A. 102 (24): 8603–8. doi:10.1073/pnas.0503072102. PMID 15941828. free fulltext
  2. ^ Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, Akbarian S (2007). "Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters". J. Neurosci. 27 (42): 11254–62. doi:10.1523/JNEUROSCI.3272-07.2007. PMID 17942719. commented at schizophreniaforum.org
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "MLL1". A list of authors is available in Wikipedia.
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