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Mitochondrial apoptosis-induced channelMAC, the Mitochondrial Apoptosis-Induced Channel, is an early marker of the onset of apoptosis[1][2]. This ion channel is formed on the outer mitochondrial membrane in response to certain apoptotic stimuli[3]. MAC activity is detected by patch clamping mitochondria from apoptotic cells at the time of cytochrome c release[4]. Additional recommended knowledge
Members of the Bcl-2 protein family regulate apoptosis by controlling the formation of MAC: the pro-apoptotic members Bax and/or Bak form MAC[4][5], whereas the anti-apoptotic members like Bcl-2 or Bcl-xL prevent MAC formation. Once formed, MAC mediates the release of cytochrome c to the cytosol, triggering the commitment step of the mitochondrial apoptotic cascade. References
Categories: Cell signaling | Programmed cell death | Apoptosis |
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Mitochondrial_apoptosis-induced_channel". A list of authors is available in Wikipedia. |