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Lorcainide


Lorcainide
Systematic (IUPAC) name
N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-yl- 4-piperidyl)acetamide
Identifiers
CAS number	59729-31-6
ATC code	C01BC07
PubChem	42884
Chemical data
Formula	C₂₂H₂₇Cl N₂O
Mol. mass	370.915 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Lorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.

References

Kesteloot H, Stroobandt R., Clinical experience with lorcainide (R 15 889), a new anti-arrhythmic drug, Arch Int Pharmacodyn Ther. 1977 Dec;230(2):225-34.
Carmeliet E, Janssen PA, Marsboom R, Van Nueten JM, Xhonneux R., Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide, Arch Int Pharmacodyn Ther. 1978 Jan;231(1):104-30.

v • d • e Antiarrhythmic agents (C01B)
class Ia	Ajmaline • Disopyramide • Prajmaline • Procainamide • Quinidine • Sparteine
class Ib	Aprindine • Lidocaine • Mexiletine • Tocainide
class Ic	Encainide • Flecainide • Lorcainide • Moricizine • Propafenone
class II	Propranolol • Metoprolol • Nadolol • Atenolol • Acebutolol • Pindolol see Beta blockers (C07)
class III	Amiodarone • Bretylium tosylate • Bunaftine • Dofetilide • Ibutilide • Sotalol
class IV	Verapamil • Diltiazem see Calcium channel blockers (C08)
class V	Adenosine • Atropine • Digoxin