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Lofexidine



Lofexidine
Systematic (IUPAC) name
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
Identifiers
CAS number  ?
ATC code N07BC04
PubChem  ?
Chemical data
Formula C11H12Cl2N2O 
Mol. mass 259.131 g/mol
Pharmacokinetic data
Bioavailability >90%
Protein binding 80–90%
Metabolism Hepatic glucuronidation
Half life 11 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

POM(UK)

Routes Oral

Lofexidine is an alpha2-adrenergic receptor agonist, can be used as a short acting (short half life) anti-hypertensive, but mostly used to help with relief from symptoms of heroin or opiate withdrawal in opiate dependency. Used primarily in the United Kingdom [1]. See also clonidine.



v • d • e
Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents (including alpha)centrally acting/antiadrenergics (Clonidine, Guanfacine, Methyldopa, Moxonidine, Rescinnamine, Reserpine, Rilmenidine) • ganglion-blocking/nicotinic antagonist (Mecamylamine, Trimethaphan) • peripherally acting/antiadrenergics (Prazosin, Guanethidine, Indoramin, Doxazosin)
VasodilatorsDiazoxide • Hydralazine • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensivesserotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan)
Low ceiling diureticsThiazide (Bendroflumethiazide, Chlorothiazide, Hydrochlorothiazide) • Chlortalidone • Indapamide • Quinethazone • Mersalyl • Metolazone • Theobromine • Cicletanine
High ceiling diureticsLoop diuretic (Bumetanide, Furosemide, Torasemide)
Potassium-sparing diureticsESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)
v • d • e
Drugs used in addictive disorders (N07B)
Nicotine dependenceNicotine - Bupropion - Varenicline - Mecamylamine - Clonidine
Alcohol dependenceDisulfiram - Calcium carbimide - Acamprosate - Naltrexone - Nalmefene - Topiramate - Clonidine
Opioid dependenceBuprenorphine - Methadone - Levacetylmethadol - Heroin - Fentanyl - Dihydrocodeine - Dihydroetorphine - Clonidine - Lofexidine - Naltrexone - Ibogaine - 18-Methoxycoronaridine - Morphine - MS-Contin
Stimulant dependenceDexamphetamine - Bupropion - Vanoxerine - Nocaine
Benzodiazepine dependenceClonidine - Diazepam - Phenytoin - Phenobarbital
Cocaine dependenceBupropion - Vanoxerine - Nocaine - Baclofen
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Lofexidine". A list of authors is available in Wikipedia.
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