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Levocabastine


Levocabastine
Systematic (IUPAC) name
1-[4-cyano-4-(4-fluorophenyl)-cyclohexyl]- 3-methyl-4-phenyl-piperidine-4- carboxylic acid
Identifiers
CAS number	79516-68-0
ATC code	R01AC02 S01GX02
PubChem	54385
DrugBank	APRD01069
Chemical data
Formula	C₂₆H₂₉F N₂O₂
Mol. mass	420.519 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	3
Excretion	?
Therapeutic considerations
Pregnancy cat.	B3(AU) C(US)
Legal status	℞ Prescription only
Routes	Ophthalmic, intranasal^[1]

Levocabastine is a selective second-generation H₁-receptor antagonist used for allergic conjunctivitis.

Levocabastine was discovered at Janssen Pharmaceutica in 1979.

References

Pipkorn U, Bende M, Hedner J, Hedner T., A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis, Allergy. 1985 Oct;40(7):491-6.
RxList (2004). Livostin Online, Description, Chemistry, Ingredients - Levocabastine. LIVOSTIN. RxList Inc. Retrieved on 9 October, 2005.
Novartis Pharmaceuticals (March 2002). LIVOSTIN^® (PDF). Retrieved on August 20, 2006.

^ RxMed: Pharmaceutical Information - LIVOSTIN NASAL SPRAY. Retrieved on 13 November, 2005.

v • d • e Decongestants and other nasal preparations (R01)
Topical: sympathomimetics, plain	Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine
Topical: antiallergic agents, excluding corticosteroids	Cromoglicic acid - Levocabastine - Azelastine - Antazoline - Spaglumic acid - Thonzylamine - Nedocromil - Olopatadine
Topical: corticosteroids	Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone
Topical: other nasal preparations	Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin
Systemic use: Sympathomimetics	Phenylpropanolamine - Pseudoephedrine - Phenylephrine